Deuce Bigalow goes to Amsterdam after a little accident including two irritating kids and a bunch of aggressive dolphins. There he meets up with his old friend T.J. Hicks. But a mysterious killer starts killing some of Amsterdam's finest gigolos and T.J. is mistaken for the extremely gay murderer. Deuce must enter the gigolo industry again to find the real murderer and clear T.J.'s name.

In the quiet waters of the Mississippi, body parts are being discovered. No one knows what is behind it all, until a huge man eating bull shark turns up. This bull shark is different, as it can breath in fresh water, making a deadly encounter between anyone who comes before it. John Sanders must now try and reach the surface, with his ex-wife and whilst being held hostage.