Every neighborhood has a Karen, and Amityville is no exception. When stealing a cursed bottle of wine from a struggling local brewery, Karen soon finds that the price to pay is far more dangerous than your average hangover. Everyone in her path becomes prey, and not even a manager can be called in to stop her.

What starts as just another delivery becomes the catalyst for life-shattering trouble. With Brian injured and evidence mounting against them, three friends find themselves on the run from the law. In a panic, Brian turns to his mentor and ringleader, Bear, and together they come up with a perfect scheme of betrayal and murder.

A psychiatric hospital is turned upside down when a mysterious drifter is admitted and assigned to room 316. Known only as John Doe, the other patients believe that he bears an uncanny resemblance to Jesus Christ.

A medical examiner conducting autopsies on victims of a terrible car crash, imagines how they may have lived their lives.