It’s 40 years since the murder of John Lennon, a moment trapped in Mickey Sharpe’s mind as he imagines that fateful night. After struggling to live on minimum wage, Mickey decides, "you’re better off being a gangster because you’ve got more of a chance."

An emotional thrill ride through the day-to-day chaos of the city's most explosive hospital and the courageous team of doctors who hold it together. They will tackle unique new cases inspired by topical events, forging fiery relationships in the pulse-pounding pandemonium of the emergency room.

As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.