Miracle at St. Anna chronicles the story of four American soldiers who are members of the all-black 92nd "Buffalo Soldier" Division stationed in Tuscany, Italy during World War II.

Psychiatrist Sam Foster has a new patient, Henry Letham, who claims to be suicidal. In trying to diagnose him, Sam visits Henry's prior therapist and also finds Henry's mother -- even though Henry has said that he murdered both of his parents. As reality starts to contradict fact, Sam spirals into an unstable mental state. Then he finds a clue as to how and when Henry may try to kill himself, and races to try to stop him.

After suddenly being dumped by the live-in girlfriend that he adores, Jude Donnelly hits the road to seek solace from his overwhelming pain. But instead of finding solace, Jude instead experiences three more years of excruciating suffering.