In 16th century Rome, Rampín, a friendly and shameless rogue, exploits his arts of deception. He lives with his aunt, Napolitana, a pimp dedicated to the same trades as his nephew. With the arrival of a beautiful Andalusian, Lozana, her fortune enters their house by making her the most beautiful courtesan in Rome. Lozana and Rampín reach an agreement: he will be at her service, taking her lovers home, and she will treat him like a king and give him the best, something that others will never have. But one fine day, Don Sancho, a handsome Spaniard, falls in love with her.

Zoraida is a single mother and bearded woman in a circus, while Charly works in transvestite shows. Together they will live a difficult and unusual love story.

Blanca and Ramiro are a married couple who are always arguing just for pleasure; but Blanca suddenly suffers a misfortune and everything changes.

Pedro is a famous singer who fall in love with a psychiatrist girlfriend, he decides to attend to the doctor with the story that he does not like women. The psychiatric nurse helps him with the girl as she is in love with the doctor.