As America's stock of athletic young men is depleted during World War II, a professional all-female baseball league springs up in the Midwest, funded by publicity-hungry candy maker Walter Harvey. Competitive sisters Dottie Hinson and Kit Keller spar with each other, scout Ernie Capadino and grumpy has-been coach Jimmy Dugan on their way to fame.

Dumped by his fiancée, Clifford Godfrey goes on vacation anyway where he ends up torn between a sober party girl and his travel agent.