Raoul Duke and his attorney Dr. Gonzo drive a red convertible across the Mojave desert to Las Vegas with a suitcase full of drugs to cover a motorcycle race. As their consumption of drugs increases at an alarming rate, the stoned duo trash their hotel room and fear legal repercussions. Duke begins to drive back to L.A., but after an odd run-in with a cop, he returns to Sin City and continues his wild drug binge.

Three people's lives are drastically changed when they are suddenly given one million dollars each by an eccentric billionaire in this pilot to a prospective new series which the producers hoped would equal the success of the original one that ran from 1955 to 1960.