A group of actors putting on an interpretive Passion Play in Montreal begin to experience a meshing of their characters and their private lives as the production takes form against the growing opposition of the Catholic church.

Skin and Bones gently introduce us to the world of anorexia and bulimia. The heroines of this moving film in which reality and fiction merge are called Annie, Andréanne, Hélène, Eisha. They have in common their youth and charm - as well as a terrible tendency to self-destruct.

One evening, after a theatrical performance, the costume designer of the play that has just ended is offered a lucrative project: to become the President of the wardrobe of a rich prince. Now, the prince in question happens to be none other than Lucifer.

Ovide Plouffe has married Rita. She still tries to attract other men even after their marriage. Unhappy Ovide feels for Marie - a young French woman he had met. But his catholic background and surrounding can't let him love another woman or divorce from his wife. So Ovide finishes with Marie and plans a trip with Rita hoping for reconciliation. At the last instant he announces to Rita that he can't make the trip. She goes alone. The plane explodes, and Ovide is suspected and arrested for this horrible crime.