Elena is a writer and is in a relationship with a painter, Fernando. Charo works as a waitress in a hotel and continues to dream of John Sargent, her platonic love, although when she discovers that the actor is gay she returns to her boyfriend Luis. Mara, a model, and Miguel is dating a sick man much older than them. Eugenia is a haute couture dressmaker and cares for her niece Soledad, who wants to be a singer. All of them have ambitions of love, but none is happy with their current situation.

Santa Rosa de Lima, who died in the capital of Peru, was barely 31 years old when she died in 1617. José María Elorrieta's film narrates the life of this young woman, daughter of Gaspar Flores, Spanish arquebusier the service of King Philip III, and of Maria de Oliva, who will become principal patron of the New World, the Philippines and West Indies in 1670.