Hawkeye and the Last of the Mohicans was set in New York's Hudson Valley during the French and Indian war in the 1750's and depicted the adventures of Hawkeye and his Indian blood brother Chingachgook, the last member of the Mohican tribe. The series based on stories by James Fenimore Cooper.

Bob Langdon, a young Pony Express rider, is given an appointment to West Point, but is forced to leave the academy as the result of political intrigue stirred up by enemies of his friend, General George A. Custer. Bob returns to the west and is made a scout for Custer's 7th Cavalry. At the Battle of Little Big Horn, Custer sends Bob with a message for aid, and Bob becomes the only survivor of the battle.