Two former co-workers, Eric and Alex, have been recently laid off of their jobs and they run into each other on a job interview. While searching for new jobs, they forge a personal relationship that involves Alex, a womanizing ladies' man, helping the naive and recently dumped Eric understand women better.

Thanks to an auto accident, a parasitic alien manages to get into a hospital. It quickly moves from the crash victim into a candy striper. Among the patients at the hospital are some rather short high school basketball players. It is through them that we watch the events unfold. The infected, or inhabited, candy striper becomes predatory. She goes after men for sex and after women to spread. Infected women develop an incredible sweet tooth and devour anything sweet they can find. The horror then spreads. As the horror takes over more of the hospital and the CDC locks it down, the basketball players and a few friends do everything they can to try and get out of the hospital. But soon it becomes evident that the problem has spread too far. Now if they manage to escape it will only be to delay the inevitable if they cannot halt the spread of aliens before they get out and take over the whole world.

Morris Buttermaker is a burned-out minor league baseball player who loves to drink and can't keep his hands to himself. His long-suffering lawyer arranges for him to manage a local Little League team, and Buttermaker soon finds himself the head of a rag-tag group of misfit players. Through unconventional team-building exercises and his offbeat coaching style, Buttermaker helps his hapless Bears prepare to meet their rivals, the Yankees.