It's 1999 and over the course of one 12-hour shift at an Arkansas hospital, a junkie nurse, her scheming cousin and a group of black market organ-trading criminals start a heist that could lead to their collective demise.

Three friends in their mid-20s struggle to navigate their professional and personal lives, colliding head on with the messy, hilarious and dreadful growing pangs of adulthood.

Iris invites her friend Jack to stay at her family's island getaway after the death of his brother. At their remote cabin, Jack's drunken encounter with Hannah, Iris' sister, kicks off a revealing stretch of days.