Harley Quinn joins forces with a singer, an assassin and a police detective to help a young girl who had a hit placed on her after she stole a rare diamond from a crime lord.

Four egocentric friends run a neighborhood Irish pub in Philadelphia and try to find their way through the adult world of work and relationships. Unfortunately, their warped views and precarious judgments often lead them to trouble, creating a myriad of uncomfortable situations that usually only get worse before they get better.