In 19th-century France, a little girl follows her two sisters into a Carmelite monastery with the goal of becoming a saint.

Professor Louis Delage is a kidney transplant specialist. He is so good in his field that his peers nickname him the "great man". But one day, one of his patients die during surgery and Delage starts doubting. Is he actually such a great man? To fight desperation he decides to take in the deceased child while devoting more time to Florence, his hitherto neglected wife.