A struggling songwriter named Dave Seville finds success when he comes across a trio of singing chipmunks: mischievous leader Alvin, brainy Simon, and chubby, impressionable Theodore.

This animated series chronicles the further adventures of renegade scientist Dr. Jumba Jookiba's beloved Experiment 626, who is now living happily as Lilo's alien buddy Stitch. Jumba’s remaining experiments have landed all over Hawaii in the form of dehydrated pods. Lilo and Stitch’s mission is to catch Stitch’s "cousins" before they fall into the clutches of the evil Dr. Jacques von Hamsterviel!