Marnie Piper prepares to begin a new school year, she asks the Halloweentown Hot Witches' Council to work toward openness between Halloweentown and the mortal world. She proposes to bring a group of Halloweentown students to her own high school in the mortal world.

After the death of his wife, world-class neurosurgeon Dr. Andrew Brown leaves Manhattan and moves his family to the small town of Everwood, Colorado. There he becomes a small-town doctor and learns parenting on the fly as he raises his talented but resentful 15-year-old son Ephram and his 9-year-old daughter Delia.