On his latest expedition, Dr. Rick Marshall is sucked into a space-time vortex alongside his research assistant and a redneck survivalist. In this alternate universe, the trio make friends with a primate named Chaka, their only ally in a world full of dinosaurs and other fantastic creatures.

Felicity Porter, a sensitive and intelligent girl from the San Francisco Bay Area, decides to give up a slot at Stanford University's pre-med program to follow her long time crush to college in New York City. Things get even more complicated when she meets her dorm's resident advisor and they fall in love.

A team of teenagers with attitude are recruited to save Angel Grove from the evil witch, Rita Repulsa, and later, Lord Zedd, Emperor of all he sees, and their horde of monsters.