Tasked by MI6 to find the mythological Pandora's Box, an ancient object supposedly containing one of the deadliest plagues on Earth, Lara Croft must beat evil Nobel Prize-winning scientist turned bioterrorist Jonathan Reiss to it.

On the day of his retirement, a veteran CIA agent learns that his former protégé has been arrested in China, is sentenced to die the next morning in Beijing, and that the CIA is considering letting that happen to avoid an international scandal.