Every neighborhood has a Karen, and Amityville is no exception. When stealing a cursed bottle of wine from a struggling local brewery, Karen soon finds that the price to pay is far more dangerous than your average hangover. Everyone in her path becomes prey, and not even a manager can be called in to stop her.

Follows six friends who break down in the middle of nowhere on the way to a concert and encounter with the Desert fiends, a deranged family that lives in the desert killing anyone they come across.