Following a bomb scare in the 1960s that locked the Webers into their bomb shelter for 35 years, Adam now ventures forth into Los Angeles to obtain food and supplies for his family, and a non-mutant wife for himself.

Doug is a Secret Service Agent who has just completed his stint in charge protecting Tess Carlisle—the widow of a former U.S. President, and a close personal friend of the current President. He finds that she has requested that he not be rotated but instead return to be her permanent detail. Doug is crushed, and—after returning—wants off her detail as she is very difficult to guard and makes her detail crazy with her whims and demands.

Bernice "Bernie" Rhodenbarr is a burglar by trade, and she runs a bookstore as well. Her friend Carl Hefler is a dog groomer. After a successful burglary, it's discovered that a dead body was in the house she burgled. As she's the only one who can be placed at the scene of the crime, she has to use her criminal skills to clear her name of the murder AND avoid getting charged with the burglary.

When a Cincinnati radio station switches from sedate music to top-40 rock 'n' roll, its staff of oddball characters is forced to switch gears quickly. New programming director Andy Travis brings in a new DJ named Venus Flytrap to work with the station's burned-out veteran, Dr. Johnny Fever. Neurotic newsman Les Nessman, eager beaver Bailey Quarters, sleazy salesman Herb Tarlek, blonde bombshell Jennifer Marlowe, who serves as the station's ultra-capable receptionist, and station manager Arthur Carlson, whose domineering mother owns WKRP, round out the eccentric bunch.