There's a deficit of good, honest women in the West, and Roy Whitman wants to change that. His solution is to bring a caravan of over 100 mail-order brides from Chicago to California. It will be a long, difficult and dangerous journey for the women. So Whitman hires hardened, cynical Buck Wyatt to be their guide across the inhospitable frontier. But as disaster strikes on the trail, Buck just might discover that these women are stronger than he thinks.

Cuban Bandleader Ricky Ricardo would be happy if his wife Lucy would just be a housewife. Instead she tries constantly to perform at the Tropicana where he works, and make life comically frantic in the apartment building they share with landlords Fred and Ethel Mertz, who also happen to be their best friends.