In 1970, Mikey and William both portrayed football cannibal Smash-Mouth in the influential cult hit, End Zone 2. Now, 50 years later, only one can wear the mask.

In an attempt to help his friend with his impotence, Jaime sets up two friends together. But after the failure, he comes in to help. What first appeared to be just a sexual experience evolves to a full romantic relationship of three people.

Once again tampering with mother nature to disastrous results, Dr. Herbert West continues his research while serving time in a maximum security prison for his previous exploits. West's limited prison-cell experiments are suddenly interrupted by the arrival of a new prison doctor and the brother of the girl who suffered from West's experiments 13 years earlier.