Government agent Daniel Leight has his radiation treatments sabotaged. He soon finds that he can now move at super speeds but only by risking metabolic damage which could prove to be fatal. 'Lightspeed' must now use his powers to go after old friend turned terrorist who is now a mutant half-snake called Python.

Newly-paroled former US Army ranger Cameron Poe is headed back to his wife, but must fly home aboard a prison transport flight dubbed "Jailbird" taking the “worst of the worst” prisoners, a group described as “pure predators”, to a new super-prison. Poe faces impossible odds when the transport plane is skyjacked mid-flight by the most vicious criminals in the country led by the mastermind — genius serial killer Cyrus "The Virus" Grissom, and backed by black militant Diamond Dog and psychopath Billy Bedlam.