Ethan Cox is poised to sell his self-driving car company when his problematic Halloween costume goes viral, nearly ending his career. Desperate to figure out a way forward, he hires a 71-year-old woman to pose as his company's figurehead.

After small town waitress Joey is sexually assaulted after a date with her old friend Mike, she befriends mysterious stranger Regina. Regina introducers her to The Cherry Bombers, an all femme gang including Beatrice, Lily, Sal, Jett, Angie, and Fala. All suffering from past traumas, together they fight a misogynistic society by targeting violent frat boys, a corrupt police force of human traffickers led by Sheriff Morel, and the dangerous alt-right group MFM (Men’s First Movement) headed by Mark Vanderhill. As Joey is drawn further into their chaotic world, Sal’s old flame, Logan County Sheriff Vernon, investigates MFM, leading to a thrilling showdown.

The Dalton gang escape to a nearby town after a train robbery goes south, but they are met by a coven of witches with sinister plans for the unsuspecting outlaws.