Robert McCall finds himself at home in Southern Italy but he discovers his friends are under the control of local crime bosses. As events turn deadly, McCall knows what he has to do: become his friends' protector by taking on the mafia.

Italy, WWII. After his anti-fascist mother is arrested, Mario spends his childhood on the streets. In 1947 they are miraculously reunited and start a new life in America. Based on the life of Mario Capecchi, 2007 Nobel Prize in Medicine.

The series tells the stories of some of the characters who work or are related to an imaginary shopping center Centovetrine, located in the center of Turin. There are many stories of love and passion, but also struggles for power and dynastic quarrels in the telefilm.