A sweeping multigenerational story set against the backdrop of the raw, roaring New York City of the late 1980s; adoption, teen pregnancy, drugs, hardcore punk rock, the unbridled optimism and reckless stupidity of the young—and old—are all major elements in this heart-aching tale of the son of diehard hippies and his strange odyssey through the extremes of late 20th century youth culture.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.