When a school project goes terribly wrong in this family friendly mystery, Cynthia Carter finds herself doing community service at mean, old Mrs. Gotham's house, rumored to be haunted. But it takes more than gossip to scare this scientist-in-training. Soon, however, Cynthia realizes that doing chores for the grumpy woman may not be her biggest problem after all. Strange happenings defy logic... and things are quickly getting worse. Enlisting the help of her two best friends and their quirky teacher, she is determined to get to the bottom of the eerie events from a purely scientific viewpoint. But while they may have it down to a science, the resident ghosts seem to have other plans.

Felicity Porter, a sensitive and intelligent girl from the San Francisco Bay Area, decides to give up a slot at Stanford University's pre-med program to follow her long time crush to college in New York City. Things get even more complicated when she meets her dorm's resident advisor and they fall in love.

After a series of mysterious deaths befalls their small town, an offbeat group of friends led by Sidney Prescott become the target of a masked killer.