Thanks to his police officer father's efforts, Shawn Spencer spent his childhood developing a keen eye for detail (and a lasting dislike of his dad). Years later, Shawn's frequent tips to the police lead to him being falsely accused of a crime he solved. Now, Shawn has no choice but to use his abilities to perpetuate his cover story: psychic crime-solving powers, all the while dragging his best friend, his dad, and the police along for the ride.

Corky Romano is a bumbling, simpleton, veterinarian and the youngest, outcast son of an aging gangster, named Pops Romano, who calls upon Corky to infiltrate the local FBI and retrieve and destroy evidence being used to incriminate Pops for racketeering charges.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.