On a flight from Los Angeles to Paris, a mad scientist on the run from the CIA is transporting a coffin containing the body of a colleague infected with a genetically modified virus. While the 747 crosses a violent thunderstorm, the instability of the aircraft allows the corpse to get out of its container.

A Las Vegas team of forensic investigators are trained to solve criminal cases by scouring the crime scene, collecting irrefutable evidence and finding the missing pieces that solve the mystery.