Ellen Saunders is an heiress on a cruise to Europe being pursued by a day laborer mistaken for a prominent mining engineer. During the cruise, he foils two crooks trying to get their hands on her lucrative nickel mine.

A doctor's research into the roots of evil turns him into a hideous depraved fiend.

Ziegfeld Follies headliner Billie Burke starred in a handful of silent films, of which Arms and the Girl was the second. Burke plays an American lass who journeys to Europe to be reunited with her fiance. Not only has her sweetheart been unfaithful, but she arrives on the continent just as World War I breaks out.