An astronaut goes into space with a chimpanzee. When they return to Earth after their orbit, it is discovered that the chimp has the brains of the astronaut, and the astronaut has the brains of the chimp. Complications ensue.

Assassins take a flight controller's family hostage to force him into revealing the aircraft carrying their quarry.

The series initially starred veteran movie supporting actor Ward Bond as the wagon master, later replaced upon his death by John McIntire, and Robert Horton as the scout, subsequently replaced by lookalike Robert Fuller a year after Horton had decided to leave the series. The series was inspired by the 1950 film Wagon Master directed by John Ford and starring Ben Johnson, Harry Carey Jr. and Ward Bond, and harkens back to the early widescreen wagon train epic The Big Trail starring John Wayne and featuring Bond in his first major screen appearance playing a supporting role. Horton's buckskin outfit as the scout in the first season of the television series resembles Wayne's, who also played the wagon train's scout in the earlier film.