Liza Miller, a suddenly single stay-at-home mother, tries to get back into the working world, only to find it’s nearly impossible to start at the bottom at 40-year old. When a chance encounter convinces her she looks younger than she is, Liza tries to pass herself off as 26 and lands a job as an assistant at Empirical Press. Now she just has to make sure no one finds out the secret only she and her best friend Maggie share.

Arnie Miller, a small town guy from rural Connecticut, is forced to navigate a complicated weekend when convinced to go visit an ex girlfriend in Chicago.

Raymond "Red" Reddington, one of the FBI's most wanted fugitives, surrenders in person at FBI Headquarters in Washington, D.C. He claims that he and the FBI have the same interests: bringing down dangerous criminals and terrorists. In the last two decades, he's made a list of criminals and terrorists that matter the most but the FBI cannot find because it does not know they exist. Reddington calls this "The Blacklist". Reddington will co-operate, but insists that he will speak only to Elizabeth Keen, a rookie FBI profiler.