In the year 2524, four centuries after humans started colonizing the outer planets, retired General James Ford gets called back into service when a hostile alien fleet attacks soldiers on a remote planet. The threat against mankind soon escalates into an interstellar war as Ford and a team of elite soldiers try to stop the imminent attack before it's too late.

A young Victoria "Vic" McQueen discovers she has the power to unlock portals that help her find lost objects. As she delves further into this hidden universe, she encounters many other "inscape travelers" - some benevolent, and some who have been corrupted by their power. When Vic encounters Charlie Manx, an immortal who stays that way by feeding off of the souls of children, she makes a sworn enemy of Manx.