When Emily Thorne moves to the Hamptons, everyone wonders about the new girl, but she knows everything about them, including what they did to her family. Years ago, they took everything from her. Now, one by one, she's going to make them pay.

Two not-too-bright party girls reinvent themselves for their high school reunion. Armed with a borrowed Jaguar, new clothes and the story of their success as the inventors of Post-It notes, Romy and Michele descend on their alma mater, but their façade crumbles quickly.

Dr. Mark Sloan is a good-natured, offbeat physician who is called upon to solve murders.