The arrival in a small mountain town of a dissheveled stranger launches a series of murders committed by some sort of animal. As the town doctor and his daughter attempt to help the stranger, the sheriff investigates the murders; and they uncover a sinister experiment involving two rogue scientists, a car accident victim, his wife and children, and a serum that causes a man to turn into a ravaging werewolf.

Highway Patrol was a syndicated, fictional police action series produced from 1955 to 1959, concerning the activities of the highway patrol and their leader, Dan Matthews (who held no rank). Although filmed in and around the Los Angeles area, the state setting for the stories was never identified, and city and street names were fictionalized.