When her husband dies en route to America, Martha Price and her daughter Hilary are left to carry out his dream: the introduction of Hereford cattle into the American West. They enlist Sam "Bulldog" Burnett in their efforts to transport their lone bull, a Hereford named Vindicator, to a breeder in Texas, but the trail is fraught with danger and even Burnett doubts the survival potential of this "rare breed" of cattle.

Passengers on a ship traveling from Mexico to Europe in the 1930s represent society at large in that era. The crew is German, including the ship's Dr. Schumann, who falls in love with one of the passengers, La Condesa. A young American woman, Jenny, is traveling with the man she loves, David. Jenny is fascinated and puzzled by just who some of the other passengers are.

Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.

Richard Kimble is falsely convicted of his wife's murder and given the death penalty. En route to death row, Kimble's train derails and crashes, allowing him to escape and begin a cross-country search for the real killer, a "one-armed man". At the same time, Dr. Kimble is hounded by the authorities, most notably dogged by Police Lieutenant Philip Gerard.