The biography of Dr. W.T. Morgan, a 19th century Boston dentist, during his quest to have anesthesia, in the form of ether, accepted by the public and the medical and dental establishment.

Rocksford, New England, 1672. Puritan witch hunter Jonathan Wooley is cursed after burning a witch at the stake: his descendants will never find happiness in their marriages. At present, politician Wallace Wooley, who is running for state governor, is about to marry his sponsor's daughter.