Inspired by real life events, Madame Luna tells the story of an Eritrean refugee who is washed ashore in Libya and survives to become one of the most notorious human smugglers, with deep ties to the Italian Mafia. Now trapped in Italy and forced to experience the brutalising reality endured by the people she has exploited in the past, Madame Luna must try to find a way out before she is recognized and brought to justice. In the process she forms a powerful bond with a younger version of herself.

Rosa is a young rebel girl who lives with her grandmother and her uncle in a remote part of Calabria, in Southernmost Italy. Her mother's untimely death when Rosa was a child casts a gloomy shadow on her present life.

Matilde lives in a cramped house on the beach with his grandfather. To make some money, she scours the sand with her metal detector hoping to find something of value. On a cold winter morning, Matilde will discover an object which will change her life forever.

The daily routine of a young couple is disturbed by some shocking news. A strange dream appears to herald a terrible and, at the same time, wonderful truth.

Middle-aged family man Arnaldo is kicked out by his wife because of a misunderstanding. Instead of despairing, Arnaldo takes advantage of the situation to turn around his unsatisfying adult life by going to live in a flat shared with four university students.