Detective John Traveller (Peter Coyote) is convicted of the murder of his wife and her lover. His partner and friend, Detective Matthew Ransom, becomes very upset, affecting his marriage that was not working well. The lover of John's wife was the son of Luke Williams, a detective of the same department, and he does not accept the death of his son. After the trial and conviction of John, Matthew separates from his wife Mary Ramson, being sexually arrested by John's daughter Jude. Meanwhile, a serial killer kills the enemies of John, leaving clues in the crime scenes relatives to Sherlock Holmes tales and Matthew suspects of Jude.

Clayton Pierce is an agent working under deep cover. Although he is a top agent, he is questioning his loyalty after twenty years of service. His devotion has already cost him his wife, family and personal life. During a de-briefing from his last assignment, he is unknowingly administered the drug Oblivion, which destroys brain cells causing permanent memory loss. Within a few days of injection, the drug's effects become irreversible. Clayton will not only lose his memory, he will lose his identity as well. He realizes he can no longer rely on anyone at the agency to help him, not even his boss, Agent LaNova. With nowhere left to go, he appeals to his ex-wife, Kate, for help. Clayton and Kate must locate the antidote before it's too late.