This follow-up to the George Romero/Stephen King-launched anthology series features five new tales of horror and a wraparound. The main stories deal with alternative realities ("Alice"), possessed communication devices ("The Radio"), vampires and serial killers in lust ("Call Girl"), mad inventors ("The Professor's Wife"), and hauntings from beyond the grave ("Haunted Dog").

ER explores the inner workings of an urban teaching hospital and the critical issues faced by the dedicated physicians and staff of its overburdened emergency room.