On April Fools' Day, just before her wedding, a bride pranks her fiancé by saying that she thinks that they've lost that spark and that they should call off the wedding and break up, only to discover that he feels the exact same way.

It’s 1958 Manhattan and Miriam “Midge” Maisel has everything she’s ever wanted - the perfect husband, kids, and Upper West Side apartment. But when her life suddenly takes a turn and Midge must start over, she discovers a previously unknown talent - one that will take her all the way from the comedy clubs of Greenwich Village to a spot on Johnny Carson’s couch.