When the prospect of an Elwood City concert by the Backstreet Boys drives everyone else into a frenzy, a disgusted Francine decides to counter with an "anti-cute" band of her own called U Stink. But things don't go quite the way she had planned.

The show revolves around the lives of 8-year-old Arthur Read, an anthropomorphic aardvark, his friends and family, and their daily interactions with each other.