The lives of head nurse Rachel Gunn and her co-workers at Little Innocence Hospital in Nebraska, where Rachel is often at odds with egotistical surgeon David Dunkel.

Yale scholar Matt Carter introduces his wealthy fiancée, Allison, to his family, and initially everything goes smoothly. However, it isn't long before Allison learns that Matt has lied to her about his relatives to mask their failures and dysfunctions. His brother, Tim, flunked out of school and developed a drinking problem, and Matt struggles to keep his own troubling secret from his less than tolerant parents.