After runaway Ben Young is robbed and left on his own, he is taken in by Lil, the head of a Chicago brothel. Acting as a surrogate mother for Ben, who thinks she runs a boardinghouse, Lil gets him a job with Francis Sullivan at the local newspaper. As Ben is exposed to the workings of the big city, he realizes the extent of government corruption and sets out on the daunting task of reforming Chicago politics, finding several allies along the way.

In New York City, bright but naive New Englander Anne Welles becomes a secretary at a theatrical law firm, where she falls in love with attorney Lyon Burke. Anne befriends up-and-coming singer Neely O'Hara, whose dynamic talent threatens aging star Helen Lawson and beautiful but talentless actress Jennifer North. The women experience success and failure in love and work, leading to heartbreak, addiction and tragedy.