CSI: Miami follows Crime Scene Investigators working for the Miami-Dade Police Department as they use physical evidence, similar to their Las Vegas counterparts, to solve grisly murders. The series mixes deduction, gritty subject matter, and character-driven drama in the same vein as the original series in the CSI franchise, except that the Miami CSIs are cops first, scientists second.

Student Alice Jeffries (Anne Jensen) is on vacation in Mexico with her friend Carmen. When the two girls are arrested by the local police for drug possession, the U.S. Drug Enforcement Administration (DEA) gets involved and quickly discovers that the Mexican authorities are unusually uncooperative. It's suspected that Alice was not arrested by chance, because after all she is the daughter of the Californian governor. The governor now pulls all the strings to free his little daughter and does not hesitate to send US agents to Mexico.

Al Bundy is an unsuccessful middle aged shoe salesman with a miserable life and an equally dysfunctional family. He hates his job, his wife is lazy, his son is dysfunctional (especially with women), and his daughter is dim-witted and promiscuous.