At the height of the frontier era, a train races through the Rocky Mountains on a classified mission to a remote army post. But one by one the passengers are being murdered, and their only hope is the mysterious John Deakin, who's being transported to face trial for murder.

A community of fairy tale characters live in hiding from the human world in New York City. But when one Fable's identity is exposed, an old ally must return to face the community's greatest threat.