Jack Sadelstein, a successful advertising executive in Los Angeles with a beautiful wife and kids, dreads one event each year: the Thanksgiving visit of his twin sister Jill. Jill's neediness and passive-aggressiveness is maddening to Jack, turning his normally tranquil life upside down.

Mark Anderson, a recent stroke victim who is frail and weak. Also, his best friend Thomas, a classic over the hill drag queen desperate for love and happiness. Mark and Thomas have a master plan, to find Mark's son, James Anderson the love of his life once and for all.

Life’s good for deliveryman Doug Heffernan, until his newly widowed father-in-law, Arthur, moves in with him and his wife Carrie. Doug is no longer the king of his domain, and instead of having a big screen television in his recently renovated basement, he now has a crazy old man.