Ride with the Devil follows four people who are fighting for truth and justice amidst the turmoil of the American Civil War. Director Ang Lee takes us to a no man's land on the Missouri/Kansas border where a staunch loyalist, an immigrant's son, a freed slave, and a young widow form an unlikely friendship as they learn how to survive in an uncertain time. In a place without rules and redefine the meaning of bravery and honor.

About to executed by the forces of the Antichrist, a fundamentalist Christian guerrilla is rescued by an Antichrist agent pretending to be a double agent for the Believers' Underground. The agent hopes to trick the Christian into leading her to the dissidents' hidden base. Meanwhile, Armageddon and the Second Coming draw nigh.