Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.

The staff of the Back Bay Mainline, a Boston underground newspaper that rose to prominence in the 1960s, struggles with the shifting social climate of the '70s amid rumors that the paper is about to be sold to a media giant.