Dave and Hank ride out of Death Valley, heading for the town of Mesa, but stop to rest in Alkali Springs, twenty miles from Mesa. Walking along the saloon porch, they overhear through an open window, two unseen men plotting to rob the Mesa bank that afternoon. One is a Spanish voice and the other American. Dave and Hank head for Mesa to get there before the hold-up and, there, they see the men whose voices they had heard; Sheriff Jeffries and Ortego.

A cowboy looking to sell an inherited ranch changes his mind after a female neighbour arrives on the scene.

Terry Macy (Reed Howes), the son of a newspaper's founder, is assigned to investigate a mysterious warning signed '30' (newspaper term for 'The End)that has been sent to a local politician. Terry is captured at a clandestine meeting of the 'Mystic Medicants", an outlaw band, where he overhears the plans of a plot to kill his uncle, Robert Macy, publisher of the newspaper. Terry must also, according to his father's will, get married within a short period of time is he is to inherit the newspaper.

College boy Clarence Butts has been sent west by the Doctor to join McKenzie's circus. There he finds Calamity Jane running roughshod over everyone. So the dude decides to tame her.